Indo-American Psychiatric Association   
Dr.Anand Kumar


Late-life Depression: Clinical and Neurobiological Substrates

Dr. Anand Kumar



Late-life depression (MDD) is a common behavioral disturbance in the elderly and is associated with considerable morbidity.  MDD is frequently associated with suicide attempts, medical comorbidity and cognitive impairment  - features that distinguish late-life MDD from depression in non – geriatric adult patients.  Neuroimaging, especially magnetic resonance imaging, approaches have been used to characterize structural and physiological abnormalities in MDD.  These include estimates of brain volumes, high intensity lesion volumes and related studies examining the structural integrity of macromolecular proteins and chemicals such as choline and myoinositol in critical brain regions.

 The focus of this presentation will be on the unique clinical features of MDD in the elderly and the neurobiological substrates that underlie this disorder.  Links between cognition/behavioral phenomena and anatomical and structural changes will be made in an attempt to clarify the underlying neuronal circuitry of MDD in the elderly.